Avastin in ophthalmology: reviews, instructions for use and composition
In medicine, there are cases when the means,developed for the treatment of certain diseases, show good results in the therapy of others. This occurs as a result of numerous experiments before the drug reaches the consumer. This happened with a drug developed for the treatment of cancer tumors, called Avastin. In ophthalmology, the reviews and the results of the therapy made them think about the purpose and the disease for which it is better to use the drug.
Visual loss is one of the most sad satellitesaging of a person. Until recently, most of the processes inside the eye were difficult to control, but in recent years, ophthalmology made discoveries that prevented the development of visually dangerous diseases in blindness.
For this purpose, preparations of variousgroups, for example, with a great success, an agent for the treatment of oncology Avastin in ophthalmology is used. The patient's feedback is confirmed by the fact that the drug has a high degree of effectiveness. But in order to understand how effective it is, it is necessary to consider the mechanism of development of the ailments of the eye.
Mechanism of disease development
The loss of vision occurs as a result ofpathological proliferation of blood capillaries. Emerging new vessels sprout through the membrane, disrupting the structure of the eye. Moreover, the abundance of blood vessels provokes frequent hemorrhages, which can be felt by a person and affect the quality of vision. Damaged capillaries are scarred, and a large amount of connective tissue disrupts the process of feeding the retina of the eye.
This point can be considered a starting pointvisual impairment. It is important to note that vision with such a development of somatic pathology is not lost completely, since the peripheral usually remains. But nevertheless, the quality of human life falls significantly.
Despite the fact that the picture of the disease looksextremely depressingly, with timely diagnosis of pathology can be stopped, retaining the vision. For this purpose, Avastin is used in ophthalmology. Reviews of patients and doctors confirm positive statistics.
How the drug works
"Avastin" is an antitumor drug,It has been used in oncology for many years and demonstrates excellent results. The principle of his work is in blocking the process of tissue proliferation, pathological cell division. Therefore, by stopping the growth of new vessels, it relieves the very cause of the disease.
For a long time,whether the oncological preparation "Avastin" in ophthalmology can make the necessary therapeutic effect. Reviews of scientists and doctors said that the molecular weight of its active substance is too high: it is about three times the mass of molecules of other drugs with a similar effect. Therefore, in theory, the drug can not overcome the layer of the retina membrane, and therefore, have a therapeutic effect.
But, according to studies, "Avastin"perfectly penetrates into all layers of the retina, reducing the rate of proliferation of blood capillaries. With timely diagnosis and treatment, you can fully preserve your eyesight.
If we consider Avastin, the instructionon the application, reviews and analogues with guidance for use speak exclusively about the internal reception, which usually occurs in the treatment of cancer. Therefore, the side effects of the drug is as follows:
- internal bleeding;
- disorders in the work of the digestive tract;
The list of side effects when using the drug during treatment is very wide, as with any drug for the treatment of oncology.
Application in ophthalmology
But in this case the drug is not introducedintravenously, but directly into the vitreous. And secondly, the dosage is significantly different from that used for oncology. For example, about 500 mg of the drug is injected intravenously, while in the eye it is only 1.25 mg.
Nevertheless, one side effect of takingAvastin exists: a hemorrhage at the injection site, a burning sensation and accompanying tear. No serious side effects were found either in the studies or in practice.
Mode of application
Dosage of 1.25 mg is administered internally vitreousbody once a month, or three, or four times. After that, you can evaluate the effect of Avastin in ophthalmology. Patients' responses show that immediately after the course, an increase in visual acuity is noted in 4 out of 10 subjects. In 6 out of 10 people, the course of treatment leads to the stabilization of vision, that is, to a decrease in the rate of progression of capillary overgrowth and scarring.
The effect is that the retina of the eyebecomes thinner, that is, its permeability and nutrition of the eye tissues increases. Usually, the patient feels an increase in visual acuity right after the first injection, and subsequent injections only fix the effect. How often it is necessary to repeat injections depends on the anatomical features of a person. According to statistics, the next injection course is performed 2-3 months later.
The drug is not recommended for usechildren, pregnant women and nursing mothers. Also, with great caution should be applied "Avastin" in the event that there are violations of the liver and kidneys, especially the functional failure of these organs.
But we need to take into account the fact that thesecontraindications are only valid with intravenous administration, and when injected into the eye they may not have relevance. In any case, the decision on the appointment of Avastin in ophthalmology, which can be obtained from any appropriate clinic, should be made by the attending physician.
However, it should be remembered that with the classicaluse of the drug, doctors are strongly advised to protect themselves in order to avoid unwanted pregnancies. Using the drug as an agent for eye treatment, it is also necessary to take this information into account when planning family.
Throughout the world, this way of preserving visionIt has been used for a long time, but other drugs are used for this purpose, for example, Macugen and Lucentis. But in recent years more and more studies have been carried out, which show that Avastin is very effective in ophthalmology. But as long as there is no information on the long-term consequences of using the drug for eye treatment, it will officially remain a drug for the therapy of oncological tumors.
To date, in thesays nothing about eye treatment. Therefore, the only source of information about the use of Avastin in ophthalmology is feedback. The price of the drug is quite loyal, which makes it more affordable in comparison with analogues.
The term "analog" is usually understood to meana drug that has a similar composition, the same active substance. There are no such drugs on the market of Russian pharmaceutical products, which can be determined by comparing the formulations, having studied the documents to which the instructions for use applied to the Avastin preparation apply. Analogues, the price of which ranges from affordable to quite expensive, have a similar list of indications. But a similar mechanism of influence is due to other components.
To such preparations which can be found in any drugstore, concern:
- "Herceptin lyophilizate."
Legitimacy of use
Official medicine today is notrecommends the use of Avastin in ophthalmology. Patients' reviews are often positive, but there is also a significant degree of risk that you need to know about.
There is a contradiction associated with the drug"Avastin": instructions for use in ophthalmology (feedback from scientists and other sources, too) does not allow the use of funds in the treatment of the eye. The manufacturer of the drug officially declares that neither the original nor the generic version of the drug "Bevacizumab", manufactured in Russia, should not be used in ophthalmology. Confirmation of this information can be found on the website of Roszdravnadzor.
But on certain resources, for example, on sites,devoted to ophthalmology, you can often find information that the drug is very effective for eye diseases. This is due to the fact that scientific research on the use of this drug has been and continues to be conducted, showing good results. However, before the full safety of the drug is proven against the background of its high effectiveness, the instruction will not include the relevant information in the section "Indications for Use".
In this regard, "Avastin" is used only incases of extreme necessity, when the alternative is complete loss of vision. At the conducted experiment in one of the clinics of Russia it was revealed that the injection of Avastin did not lead to serious consequences, did not worsen vision and did not lead to blindness. But patients complained of tearing and burning in the eye area.
Thus, Avastin is a highly efficienta drug for the treatment of oncological tumors. The practice, according to which Avastin began to take on ophthalmology, reviews patients is mostly positive. But with the possibility of choice, it is necessary to resort to using only those drugs that are designed specifically to solve a specific problem, especially in the pharmaceutical market, there are already special drugs that can reduce the progression of diabetic retinopathy and wet form of macular degeneration.
Therefore, "Avastin" can only be used in the most extreme cases under the close supervision of a doctor.